文部科学省科学技術振興調整費「京都大学・キヤノン協働研究プロジェクト」高次生体イメージング先端テクノハブ

Molecular probe

Development of innovative molecular probes

The goal of this group is development of innovative molecular probes for minimally invasive and diagnostic imaging such as optical imaging and MRI on the basis of new principles. For example, highly luminescent polymer nano-particles in near-infrared region for optical imaging have been developed. A novel dendrimer Gd-MRI contrast agent is designed and synthesized successfully, and its high T1 attenuating capability is clarified in vitro and in vivo. Novel ¹⁹F-MRI probes are developing and methods for multiple-resonance MRI are to be established. Development of multi-functional molecular probes for photoacoustic tomography and mammography is in progress.

Development of disease-specific molecular probes

Molecular probes sensitive to disease-specific environments are developing for the early detection and therapy of cancer, Alzheimer’s disease and adult diseases such as diabetes and cardiovascular disease. With aiming practical use, screening and optimization of the developed molecular probes by optical imaging systems are essential for evaluation of their specificity, bio-compatibility, and metabolism.

Group

Teruyuki Kondo	Advanced Biomedical Engineering Research Unit, Professor	[Laboratory]
Hideo Saji	Graduate School of Pharmaceutical Sciences, Professor	[Laboratory]
Yasuo Mori	Graduate School of Engineering, Professor	[Laboratory]
Masahiro Ohshima	Graduate School of Engineering, Professor	[Laboratory]
Masahiro Shirakawa	Graduate School of Engineering, Professor	[Laboratory]
Itaru Hamachi	Graduate School of Engineering, Professor	[Laboratory]
Yasuhiko Tabata	Institute for Frontier Medical Sciences, Professor	[Laboratory]
Michiyuki Matsuda	Graduate School of Medicine, Professor	[Laboratory]
Michiaki Mishima	Graduate School of Medicine, Professor	[Laboratory]
Nobuya Inagaki	Graduate School of Medicine, Professor	[Laboratory]
Yoshiharu Sakai	Graduate School of Medicine, Professor	[Laboratory]
Shunsaku Kimura	Graduate School of Engineering, Professor	[Laboratory]
Hidehito Tochio	Graduate School of Science, Professor	[Laboratory]
Shigeki Kiyonaka	Graduate School of Engineering, Associate Professor	[Laboratory]
Shinsuke Nagamine	Graduate School of Engineering, Associate Professor	[Laboratory]
Masaya Yamamoto	Institute for Frontier Medical Sciences, Associate Professor	[Laboratory]
Hiroyuki Aoki	Advanced Biomedical Engineering Research Unit, Program-Specific Associate Professor	[Laboratory]
Yu Kimura	Research and Educational Unit of Leaders for Integrated Medical System, Program-Specific Associate Professor	[Laboratory]
Koji Miki	Graduate School of Engineering, Associate Professor	[Laboratory]
Yuji Kamioka	Graduate School of Medicine, Program-Specific Assistant Professor	[Laboratory]
Aoi Son	Graduate School of Engineering, Program-Specific Assistant Professor	[Laboratory]
Kayo Imamura	Graduate School of Engineering, Program-Specific Researcher	[Laboratory]
Keiko Yoshizawa	Institute for Frontier Medical Sciences, Program-Specific Researcher	[Laboratory]
Takeshi Shigemitsu	Graduate School of Engineering, Program-Specific Researcher	[Laboratory]
Yasuhiro Aoyama	Kyoto University, Professor Emeritus	[Laboratory]
Shinsuke Sando	The University of Tokyo, Professor	[Laboratory]
Shinae Kondoh	Tokyo Institute of Technology, Professor	[Laboratory]
Hiroyuki Shinto	Fukuoka University,Professor	[Laboratory]
Hisatsugu Yamada	Tokushima University, Senior Lecturer	[Laboratory]
Kazuhito Tanabe	Aoyama Gakuin University, Professor	[Laboratory]
Tomonori Fukasawa	Hiroshima University, Assistant Professor	[Laboratory]